HPLC Column, RP C4 Butyl, 3um, 2.1mm ID x 150mm Length, 100A. Cogent Brand. 1 EA.
Additional Information:
Cogent RP C4 Butyl™ is a reversed-phase HPLC stationary phase designed for the separation of hydrophobic to moderately hydrophobic compounds. Manufactured using a traditional butyl (C4) bonded phase on ultra-high purity silica and fully double end capped, it provides excellent reproducibility, reliable peak shape, and balanced retention characteristics. As a USP L26 equivalent phase, it is commonly used as an alternative for compendial methods and for applications where lower hydrophobic retention than C8 or C18 phases is preferred.
68304-15P-2 is an HPLC column packed with 3 µm RP C4 Butyl™ particles featuring a 100 Å pore size in a 2.1 mm ID x 150 mm format. This narrow-bore configuration combines maximum chromatographic resolution with reduced solvent consumption and excellent compatibility with LC-MS instrumentation. The 150 mm length provides the highest peak capacity within this column family, while the 3 µm particles deliver greater efficiency and sharper peaks than comparable 5 µm packings. Typical operating flow rates are approximately 0.2–0.3 mL/min. Because of the low flow rates required by 2.1 mm ID columns, any HPLC system used with this column must be capable of precise and reproducible low-flow operation.
This column is particularly useful for hydrophobic and neutral compounds analyzed by reversed-phase HPLC when maximum resolving power is required. The C4 chemistry provides lower retention than C8 phases, helping reduce excessive retention while maintaining excellent separation performance. The 2.1 mm ID format is also highly favored for LC-MS applications where reduced solvent consumption and improved detector response are beneficial.
Key Benefits
RP C4 Butyl™ stationary phase
USP L26 equivalent chemistry
Fully double end capped
Traditional butyl (C4) bonded phase
Ultra-high purity silica support
3 µm particle size
Greater efficiency than 5 µm columns
Maximum peak capacity
Ideal for LC-MS methods
Reduced solvent consumption
Typical Applications
USP L26 methods
Reversed-phase HPLC
LC-MS methods
Small molecule analysis
Hydrophobic compound analysis
Neutral compound analysis
Pharmaceutical analysis
Method development
Impurity profiling
Complex sample separations
Specifications
Product Type: HPLC Column
Stationary Phase: RP C4 Butyl™
USP Classification: L26
Chromatography Mode: Reversed Phase
Bonded Phase: Butyl (C4)
Endcapping: Fully Double End Capped
Particle Size: 3 µm
Pore Size: 100 Å
Column Dimensions: 2.1 mm ID x 150 mm
Length: 150 mm
Typical Flow Rate: 0.2–0.3 mL/min
Brand: Cogent
Important Notes
Suitable for conventional HPLC and LC-MS systems
3 µm particles provide higher efficiency and sharper peaks than comparable 5 µm columns
Generates higher backpressure than larger particle columns
The 2.1 mm ID format is commonly used for LC-MS applications
Standard HPLC systems must be capable of precise and reproducible operation at approximately 0.2–0.3 mL/min
Detector flow cells should be optimized for low-volume, narrow-bore chromatography
The 150 mm length maximizes resolution and peak capacity for complex separations
Lower retention than comparable C8 stationary phases
Well suited for hydrophobic and neutral compounds
Commonly used as an alternative for USP L26 methods